Ionis Pharmaceuticals, Inc. has made multiple management transitions, effective January 15, 2018.    Brett P. Monia, a founder of Ionis, and current head of drug discovery and the inotersen program, will become chief operating officer. In his new role, Dr. Monia will assume responsibility for the company’s regulatory, patient advocacy, human resources, and business functions. These include corporate communications, investor relations, business development, alliance management, and ...